TRxADE Rx Guru. Blog for Independent Pharmacies, Pharmacist, and Pharmacy Technicians


Will “Made In China” Be Good For The Pharma Industry?

Will "Made In China" Be Good For The Pharma Industry?

In the past medications from China were looked down upon and not trusted by many physicians around the world, including their own Chinese doctors. These medications are completely unregulated and have not been approved by the Chinese FDA. On appearance alone, many of the medications look identical; however, these medicines are dangerous and even fatal partly due to a lack of expertise, a shortage of quality manufacturing facilities, a small pool of talent to choose from, and a slow approval process by the State Food and Drug Administration (SFDA).

Gradually they are raising the standards of their drug manufacturing processes. Some Chinese pharmaceutical companies are even partnering with American pharmaceutical companies to ensure better quality and a higher efficacy rate. These partnerships and the government’s efforts to incentivize privately owned businesses in China could revolutionize the pharmaceutical industry bringing costs down. Do you think this could have the potential to reduce drug prices in the U.S.? It does seem to be plausible.

Get an Additional $30-$50 on Diabetic Claims

The voice of the customer is extremely important to us. When you speak, we listen. Did you know that if you ‘TRxADE it”, you can not only save money on insulin, but you can also save money on complimentary DME products as well? Last week Courtney with Shellman Drugs in Shellman Georgia reached out to us to let us know due to TRxADE they are making an additional $30-$50 per claim by purchasing insulin, syringes, and test strips on the TRxADE buying platform.

TRxADE is your one-stop-shop for all your Diabetic needs. We compare prices for several insulin suppliers, but also for syringes and test strips as well including overstock from peer pharmacies where allowed by state law.

Courtney may look familiar as two weeks ago we received a testimonial that due to TRxADE’s savings they went their first week in years without negative losses on reimbursements!

TRxADE it!

Before you place your order with your Primary or Secondary TRxADE your order and compare pricing before buying! Save on medications especially with negative reimbursements. Many pharmacies have grown accustomed to rebates, high volume discounts or kickbacks. When you TRxADE it you get immediate savings, and hard cash immediately back into your pharmacy’s bottom line instantly. Stay profitable fellow pharmacies and join in our fight to ensure Independent Pharmacies Thrive, not just Survive! What are you waiting for? TRxADE it today!


  • Cao, G., Li, J., Li, L., Li, H., Wang, F., Wang, H., Zhang, L. (2012). Use of nonprescription medicines by patients with COPD: A survey in Chongqing Municipality, China. Chronic Respiratory Disease, 9 (2), 77-81. Retrieved from:


Drug Supply Chain Security

Drug Supply Chain Security Act

All Trxade Suppliers Are Pedigree Compliant

(AKA Track & Trace)

Drug Supply Chain Security Act (DSCSA), July 1st 2015

What You Need To Know About Trxade’s Pedigree Compliance

Quick Version:
Have peace of mind that Trxade suppliers are 100% DSCSA compliant, and as always, we have you and your best interests covered!

Be Informed:

With the new Drug Supply Chain Security Act (DSCSA) requirements and processes pharmacies must follow, Trxade makes this transition even easier. Trxade has reached out to each Supplier and confirmed each Supplier’s Pedigree process to ensure compliance. We are compliant, our suppliers are compliant, shop away with confidence!

Pharmacy: DSCSA July 1st, 2015 Checklist

Through Trxade, you have direct access to Transaction Pedigree information via Electronic Web Portal, Invoice/Pedigree Request Combo at Point of Sale, or Directly Requesting Transaction History up to six years from point of sale from each Supplier.

Supplier: DSCSA July 1st, 2015 Checklist

Each supplier will maintain point of sale transaction information, supply chain history, and transaction statements on behalf of Purchaser and provide access to documentation for up to six years after point of sale.


Drug Safety Via Track-and-Trace, You Are A Key Component
Title II of the Drug Supply Chain Security Act (DSCSA) of 2013 created a safeguard for patients to ensure they receive uncompromised medications. This system makes drug distribution affordable, clear, efficient, and transparent. The DSCSA has created a 10-year plan that includes an interoperable system to protect patients through national serialization and traceability of pharmaceutical drugs. There is a series of steps to be taken to reach complete electronic traceability and serialization by 2023. It will require product identification, product tracing, product verification, detection and response to any suspect drugs, notification of suspect drugs to the FDA, wholesaler and third party licensing reports.

Pharmacies: Steps Now (Steps 1 & 2)

The first step of this system was rolled in January 2015

  • Pharmacies can verify that they are receiving legitimate medications through authorized suppliers via a document that they will receive containing a transaction history of drug shipments every company that has owned the drug.

The second step of this system is going live on July 1, 2015

  • Pharmacies will be required to quarantine and investigate any suspicious drugs they have that may appear to be tampered with or are missing important information, such as the NDC code.
  • Create standard operating procedures for unpacking drugs.
  • The records of their investigation must be retained by the pharmacy for 6 years and any medication that is deemed tampered with, counterfeit etc., must be reported to the FDA.

Planning Ahead: 2017-2023 (Steps 3 – 5)

The third step is set to roll out in 2017

  • Drug packages will have a two-dimensional (2D) bar code with a distinct serial number on it.
  • It is recommended that the pharmacy check the authenticity of these serial numbers, but it is not required.

The fourth step is planned for 2020

  • Pharmacies can only purchase drugs with these serial numbered, 2D bar codes
  • A percentage of these serial numbers must be verified when conducting investigations into drugs that may appear unsafe, counterfeit, compromised etc.

The last and fifth step of this safety system is forecasted for 2023

  • All pharmaceutical companies and pharmacies must be a part of the fully electronic traceability system that uses unique serial numbers to eradicate illegitimate drugs.

Diane Darvey, the Director of Federal and State Public Policy for the National Association of Chain Drug Stores, states explains how this new process includes the entire supply chain, “It’s a shared responsibility and team effort. Pharmacists play an important role in that.”

TRAINING: For those seeking “FDA” training, the FDA has posted a 22 minute recorded webinar: “DSCSA Updates and Readiness Check: Requirements for Dispensers and other Trading Partners Webinar“.


Drug Shortages On The Rise

Drug Shortages On The Rise

Drug Shortages On The Rise

Global shortages of drugs are causing unnecessary surgeries, relapses of cancer, and even fatalities in the U.S. This is an ever-increasing problem that could affect you, your business, and your loved ones. In just five years, the shortage of drugs in the U.S. has risen to an amazingly high, 74%. The shortage has a broad coverage of drugs, from saline and anti-inflammatories to cancer treatments and anesthesia (Loftus, 2015). Even treatments as simple as a Vitamin A injection and pain medication can be hard to come by (Eban, 2014).

According to the Infectious Diseases Society of America, it is highly probable that in the near future, the U.S. will suffer from a drug shortage of five important injectables to prevent infection, which can have a significant negative impact on the care of our patients and the healthcare system as a whole. The FDA currently has 64 drugs on its Shortage list. To view a current list of drug shortages visit

The FDA focuses on shortages of medically necessary products since these shortages have the greatest impact on public health. The FDA lists shortages primarily of medically necessary products. Shortages that are expected to be resolved quickly or which involve only a particular strength or package size, are not usually listed on FDA’s Drug Shortage list.

Trxade Helps Acquire Drugs in Short Supply

Ketorolac Tromethamine is an example of an important anti-inflammatory medication that is in short supply. Trxade currently has 6 suppliers representing 3 different manufacturers of Ketorolac Tromethamine on its online comparison shopping platform. Trxade is a great resource to search multiple suppliers, price compare, and acquire drugs in short supply and high demand.

Causes of U.S. Drug Shortages

There are multiple factors that contribute to drug shortages, both due to a lower supply and a higher therapeutic demand. Some of the specific factors are quality requirements, internal or external price referencing, manufacturing process requirements, and even noncompliance (Weerdt, Simoens, Hombrockx, Casteels, & Huys, 2015). Knowing the exact cause of a shortage in drug supply can be difficult to determine “because manufacturers have no legal obligation to transparency” (Valquette & Laupland, 2015).

The FDA states the top reported reason a drug shortage occurs is due to quality/manufacturing issues. On their website they explain “However there have been other reasons such as production delays at the manufacturer and delays companies have experienced receiving raw materials and components from suppliers. Discontinuations are another factor contributing to shortages. FDA can’t require a firm to keep making a drug it wants to discontinue. Sometimes these older drugs are discontinued by companies in favor of newer, more profitable drugs.

With fewer firms making older sterile injectable drugs, there are a limited number of production lines that can make these drugs. The raw material suppliers the firms use are also limited in the amount they can make due to capacity issues at their facilities. This small number of manufacturers and limited production capacity for older sterile injectables, combined with the long lead times and complexity of the manufacturing process for injectable drugs, results in these drugs being vulnerable to shortage. When one company has a problem or discontinues, it is difficult for the remaining firms to increase production quickly and a shortage occurs.”


Eban, K. (2014, June).  Drug shortages: the scary reality of a world without meds. Reader’s Digest.

Loftus, P. (2015, May). U.S. drug shortages frustrate doctors, patients. The Wall Street Journal.

Valquette, L., & Laupland, K. (2015). Antimicrobial shortages: another hurdle for clinicians. The Canadian Journal of Infectious Diseases & Medical Microbiology, 26 (2), 67-68. Retrieved from:

Weerdt, E., Simoens, S., Hombroeckx, L. Casteels, M., & Huys, I. (2015, March). Causes of drug shortages in the legal pharmaceutical framework. Science Direct-Regulatory Toxicology and Pharmacology, 71 (2), 251-258. doi:10.1016/j.yrtph.2015.01.005.

Is Increased Government Regulation the Answer for High Drug Cost?

Is Increased Government Regulation the Answer for High Drug Cost?

Is Increased Government Regulation the Answer for High Drug Cost?

The Pharmaceutical industry is a highly regulated submarket in terms of what drugs get approved for national, safe, and legal consumption, however, drug pricing still remains mostly a free market. There have been some proposals to drug cost regulation, such as Clinton’s 1993, Health Security Act. Its purpose was keep pharmaceutical price increases below or steady at the average consumer price inflation. This resulted in pharmaceutical companies pledging to do so. The House Bills 2951 and 3486, discussed in an earlier post are two other proposals that focus on lowering drug prices through capitation and cost transparency. Some even propose we adopt the highly stringent regulations of the European Union (E.U.) that has increased control over drug prices since the 1980’s.

Would E.U. Price Regulations Work In The U.S.?

A 19-year sample period study was done that compared the pharmaceutical drug price regulations of the E.U. and the U.S. It’s easy to see why price control would benefit the patient in the short term, due to them saving money and being able to afford their medications. What about the long term benefits? Are there any potential risks to patients in the long term? Something to consider regarding drug price regulation is, “price constraints affect the profitability, stock returns, and R&D [research and development] of E.U. and U.S. firms. Had the U.S. used controls similar to those used in the E.U., a study estimates it would have led to 117 fewer new medicines and 4,368 fewer research jobs in the U.S.” (Golec & Vernon, 2010) during the 19 year study.

This proposes an interesting viewpoint for patients, U.S. economy, and the U.S. being a leader in R&D. Should the Government increase their regulation over the Pharma industry? A study published this week by shows that over 50% of Americans say there’s not enough government regulation when it comes to prescription drugs, 39% about right, 8% say too much, and 3% had no opinion. also reported this week “so far in the U.S., we have not been willing to run the risk of government regulation of drug pricing, just because there are so many conflicting interests and no bright line to lead government officials to choose a better price.”

Office of Pharmacy Affairs’ 340B Drug Pricing Program:

Programs like the Office of Pharmacy Affairs’ 340B Drug Pricing Program where drug manufacturers are required to provide outpatient drugs to eligible non-profit entities at significantly reduced prices to stretch scarce Federal resources as far as possible could be implemented at many levels of the Pharma supply chain, including specific programs focused solely on independent pharmacies. This allows them to reach more eligible patients and provide more comprehensive services.

The Federal government is not the only one trying to balance a checkbook and make the best of each dollar spent, if they can create programs for themselves, they can do the same for us! They have the power to create change. Will they take action? Who will lead the way? We are waiting! Stay tuned! The next few years with price transparency and big data being on the forefront change is inevitable.


Golec, J., & Vernon, J. (2010). Financial effects of pharmaceutical price regulation on R&D spending by EU versus U.S. firms. PharmacoEconomics, 28 (8). 615-628.